Protein Details: Chloride channel protein 1

Protein ID

ICDB_Pro_1572

Protein Name

Chloride channel protein 1

Gene Name

CLCN1

Organism

Canis lupus familiaris (Dog) (Canis familiaris)

Length

976 amino acids

AlphaFoldDB

AF-Q9MZT1-F1-model_v4.pdb

Function

Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction.

Sequence

MQPSQSLRRGGEQSWWGSAPQYQYMPFEHCTSYGLPSENGALQHRLHRDAGLRANTRPTQIYGHYKQQFSDKEQDTGMSKKMGSSESMDSKDEDHYSKCQGCVRRLGHVVRRKLGEDWIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYYQMQPNLPLQYLVWVTFPLTLILFSAVFCHLISPQAVGSGIPEMKTILRGVILKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSMFCGVYEQPYYYTDMLTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLQELPAFAIIGICCGFLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFIIASFTFPPGIGQFMAGELMPREAISTLFDNNTWVKHVGDPESLGRSAVWIHPRVNVIIIIFLFFIMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKFTIFVEDIMVRDVKFVSATCTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQSLLQRHLGPERRLRVAQDMARKLSELPYDGKGHQGISPEGRRESFAFVDEDEDEDLSGKPELPPLPPPHPLPSAPLSSEESNGPLPSHKQQPEAPEPADQRPSVFRSLLRCLLGRPRPTKKKTTQESMDLVDNMSPEEIEAWEQEQLSQPVCFDYCCIDQSPFQLVEQTSLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRSTTSTRKNPGGPPPPTEAWSLPEDGTGAPASPEPPAPSPSPAPLLSEAPAKVEGELEELELGESPGLEEELADILQGPSLRSTDEEDEDELIL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 189; /ligand="chloride" ; BINDING 484; /ligand="chloride" ; BINDING 578; /ligand="chloride"

Disease

Location

DOI ID

10.1016/s0014-5793(99)00926-6

RefSeq

NP_001003124.1